Publications

Hemin Prevents Increased Glycolysis in Macrophages upon Activation: Protection by Microbiota-Derived Metabolites of Polyphenols.
Carrasco-Pozo C, Tan KN, Avery VM. Antioxidants. 2020 Nov 11;9(11):1109. doi: 10.3390/antiox9111109.

Crystal structures of human ENPP1 in apo and bound forms.
Dennis ML, Newman J, Dolezal O, Hattarki M, Surjadi RN, Nuttall SD, Pham T, Nebl T, Camerino M, Khoo PS, Monahan BJ, and Peat TS. Acta Crystallographica Section D Structural Biology. 2020 Sep 1;76(Pt 9): 889-898. doi: 10.1107/S2059798320010505. PMID: 32876064

Addressing the tumour microenvironment in early drug discovery: a strategy to overcome drug resistance and identify novel targets for cancer therapy.
Kaemmerer E, Loessner D, Avery VM. Drug Discovery Today. 2020 Dec 2;S1359-6446(20)30514-6. doi: 10.1016/j.drudis.2020.11.030.

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation.
Kong IY, Rimes JS, Light A, Todorovski I, Jones S, Morand E, Knight DA, Bergman YE, Hogg SJ, Falk H, Monahan BJ, Stupple PA, Street IP, Heinzel S, Bouillet P, Johnstone RW, Hodgkin P, Vervoort SJ, Hawkins ED. Cell Reports, 2020, 33, 108290. doi:10.1016/j.celrep.2020.108290.

Metabolic Roles of Androgen Receptor and Tip60 in Androgen-Dependent Prostate Cancer.
Tan KN, Avery VM, Carrasco-Pozo C. International Journal of Molecular Sciences. 2020 Sep 10;21(18):6622. doi: 10.3390/ijms21186622.

HBO1 is required for the maintenance of leukaemia stem cells.
MacPherson L, Anokye J, Yeung MM, Lam EYN, Chan Y-C, Weng C-F, Yeh P, Knezevic K, Butler MS, Hoegl A, Chan K-L, Burr ML, Gearing LJ, Wilson T, Liu J, Choi J, Yang Y, Bilardi RA, Falk H, Nguyen N, Stupple PA, Peat TA, Zhang M, de Silva M, Carrasco-Pozo C, Avery VM, Khoo PS, Dolezal O, Dennis ML, Nuttall S, Surjadi R, Newman J, Ren B, Leaver DJ, Sun Y, Baell JB, Dovey O, Vassiliou GS, Grebien F, Dawson S-J, Street IP, Monahan BJ, Burns CJ, Choudary C, Blewitt ME, Voss AK, Thomas T, Dawson MA. Nature (2019) doi: 10.1038/s41586-019-1835-6

Fragment screening for a protein-protein interaction inhibitor to WDR5.
Dennis ML, Morrow BJ, Dolezal O, Cuzzupe AN, Stupple AE, Newman J, Bentley J, Hattarki M, Nuttall SD, Foitzik RC, Street IP, Stupple PA, Monahan BJ, Peat TS. Structural Dynamics 2019;6(6):064701. doi: 10.1063/1.5122849.

The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.
Carrasco-Pozo C, Tan KN, Rodriguez T, Avery V. International Journal of Molecular Sciences. 2019;20(21):5384. doi: 10.3390/ijms20215384

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA, McArthur GA, Sheppard KE. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17990-18000. doi: 10.1073/pnas.1901323116.

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.
Leaver DJ, Cleary B, Nguyen N, Priebbenow DL, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White KL, Katneni K, Cuellar M, Strasser JM, Dahlin JL, Walters MA, Street IP, Monahan BJ, Jarman KE, Sabroux HJ, Falk H, Chung MC, Hermans SJ, Parker MW, Thomas T, Baell JB. J Med Chem. 2019 Aug 8;62(15):7146-7159. doi: 10.1021/acs.jmedchem.9b00665.

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours.
Jones TW, Manito A, Grünewald TGP, Haber M, Jäger N, Kool M, Milde T, Molenaar JJ, Nabbi A, Pugh TJ, Schleiermacher G, Smith MA, Westermann F, Pfister SM. Nature Reviews Cancer 2019:19, 420-438 doi: 10.1038/s41568-019-0169-x

A framework for the development of effective anti-metastatic agents.
Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D, Jones PS, Jones R, Marshall JF, Panico MB, Shaw JA, Steeg PS, Sullivan M, Tong W, Westwell AD, Ritchie JWA; Cancer Research UK and Cancer Therapeutics CRC Australia Metastasis Working Group. Nature Reviews Clinical Oncology. 2019 Mar;16(3):185-204. doi: 10.1038/s41571-018-0134-8

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Bael JB, Leaver DJ, Hermans SJ, Kelly GL, Brennan MS, Downer NL, Nguyen N, Wichmann J, McRae HM, Yang Y, Cleary B, Lagiakos HR, Mieruszynski S, Pacini G, Vanyai HK, Bergamasco MI, May RE, Davey BK, Morgan KJ, Sealey AJ, Wang B, Zamudio N, Wilcox S, Garnham AL, Sheikh BN, Aubrey BJ, Doggett K, Chung MC, de Silva M, Bentley J, Pilling P, Hattarki M, Dolezal O, Dennis ML, Falk H, Ren B, Charman SA, White KL, Rautela J, Newbold A, Hawkins ED, Johnstone RW, Huntington ND, Peat TS, Heath JK, Strasser A, Parker MW, Smyth GK, Street IP, Monahan, BJ, Voss AK, Thomas T. Nature. 2018;560(7717):253-257. doi: 10.1038/s41586-018-0387-5.

Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer.
Tsoli M, Wadham C, Pinese M, Failes T, Joshi S, Mould E, Yin JX, Gayevskiy V, Kumar A, Kaplan W, Ekert PG, Saletta F, Franshaw L, Liu J, Gifford A, Weber MA, Rodriguez M, Cohn RJ, Arndt G, Tyrrell V, Haber M, Trahair T, Marshall GM, McDonald K, Cowley MJ, Zieglar DS. Cancer Biology and Therapy 2018:19(12):1078-1087 doi: 10.1080/15384047.2018.1491498

MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.
Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, Whitehead L, Putoczki TL, Preaudet A, Tsui C, Nowell CJ, Ward RL, Hawkins NJ, Desai J, Gibbs P, Ernst M, Street I, Buchert M, Sieber OM. Cancer Discov. 2018 Aug;8(8):988-1005. doi: 10.1158/2159-8290.CD-17-0909.

Innovative in vitro models for breast cancer drug discovery.
Kaemmerer E, Rodriguez Garzon T, Lock A, Lovitt C and Avery VM.  Drug Discovery Today: Disease Models. Invited review article. 2017 March 18: 21: 11-16. DOI:10.1016/j.ddmod.2017.02.002

Reduced abundance of the E3 ubiquitin ligase E6AP contributes to decreased expression of the INK4/ARF locus in non-small cell lung cancer.
Gamell C, Gulati T, Levav-Cohen Y, Young RJ, Do H, Pilling P, Takano E, Watkins N, Fox SB, Russell P, Ginsberg D, Monahan BJ, Wright G, Dobrovic A, Haupt S, Solomon B, Haupt Y. Sci Signal. 2017:10(461). pii: eaaf8223. doi: 10.1126/scisignal.aaf8223.

Ubiquitin ligase E6AP mediates nonproteolytic polyubiquitylation of β-catenin independent of the E6 oncoprotein.
Kuslansky Y, Sominsky S, Jackman A, Gamell C, Monahan BJ, Haupt Y, Rosin-Arbesfeld R, Sherman L. J Gen Virol. 2017:97(12):3313-3330. doi: 10.1099/jgv.0.000624

Cancer drug discovery: recent innovative approaches to tumor modeling.
Lovitt CJ, Shelper TB, Avery VM. Expert Opin Drug Discov. 2016:11(9):885-94 doi: 10.1080/17460441.2016.1214562

ABC transporters as mediators of drug resistance and contributors to cancer cell biology.
Fletcher JI, Williams RT, Henderson MJ, Norris MD, Haber M. Drug Resist Updates. 2016:26: 1-9.  doi: 10.1016/j.drup.2016.03.001

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines.
Cursons J, Leuchowius KJ, Waltham M, Tomaskovic-Crook E, Foroutan M, Bracken CP, Redfern A, Crampin EJ, Street I, Davis MJ & Thompson EW. Cell Communication and Signaling. 2015:13: 26 doi: 10.1186/s12964-015-0106-x

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications.
Greenall SA, Donoghue JF, Van Sinderen M, Dubljevic V, Budiman S, Devlin M, Street I, Adams TE & Johns TG. Oncogene. 2015:34(41):5277-87  doi: 10.1038/onc.2014.448

High throughput screening of human leukemia xenografts to identify dexamethasone sensitizers.
Toscan CE, Failes T, Arndt GM & Lock RB. J Biomol Screen. 2014:19(10):1391-401 doi: 10.1177/1087057114546550